AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension

Rationale: Endothelial dysfunction plays an integral role in pulmonary hypertension (PH). AMPK (AMP-activated protein kinase) and ACE2 (angiotensin-converting enzyme 2) are crucial in endothelial homeostasis. The mechanism by which AMPK regulates ACE2 in the pulmonary endothelium and its protective...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Zhang, Jiao, Dong, Jianjie, Martin, Marcy, He, Ming, Gongol, Brendan, Marin, Traci L., Chen, Lili, Shi, Xinxing, Yin, Yanjun, Shang, Fenqing, Wu, Yan, Huang, Hsi-Yuan, Zhang, Jin, Zhang, Yu, Kang, Jian, Moya, Esteban A., Huang, Hsien-Da, Powell, Frank L., Chen, Zhen, Thistlethwaite, Patricia A., Yuan, Zu-Yi, Shyy, John Y.-J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118028/
https://ncbi.nlm.nih.gov/pubmed/29570986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201712-2570OC
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