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ERS Special Article. Reversing Mechanoinductive DSP Expression by CRISPR/dCas9–mediated Epigenome Editing
Rationale: DSP (desmoplakin), the most abundant component of desmosomes, which maintain the mechanical integrity of epithelium, is a genome-wide association study–identified genetic risk locus in human idiopathic pulmonary fibrosis (IPF). Subjects with IPF express a significantly higher level of DSP...
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| Publicado no: | Am J Respir Crit Care Med |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Thoracic Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6118013/ https://ncbi.nlm.nih.gov/pubmed/29924937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201711-2242OC |
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