Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

Tolerance to self-antigens prevents the elimination of cancer by the immune system(1,2). We used synthetic chimeric antigen receptors (CARs) to overcome immunological tolerance and mediate tumor rejection in patients with chronic lymphocytic leukemia (CLL). Remission was induced in a subset of subje...

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Vydáno v:Nat Med
Hlavní autoři: Fraietta, Joseph A., Lacey, Simon F., Orlando, Elena J., Pruteanu-Malinici, Iulian, Gohil, Mercy, Lundh, Stefan, Boesteanu, Alina C., Wang, Yan, O’Connor, Roddy S., Hwang, Wei-Ting, Pequignot, Edward, Ambrose, David E., Zhang, Changfeng, Wilcox, Nicholas, Bedoya, Felipe, Dorfmeier, Corin, Chen, Fang, Tian, Lifeng, Parakandi, Harit, Gupta, Minnal, Young, Regina M., Johnson, F. Brad, Kulikovskaya, Irina, Liu, Li, Xu, Jun, Kassim, Sadik H., Davis, Megan M., Levine, Bruce L., Frey, Noelle V., Siegel, Donald L., Huang, Alexander C., Wherry, E. John, Bitter, Hans, Brogdon, Jennifer L., Porter, David L., June, Carl H., Melenhorst, J. Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117613/
https://ncbi.nlm.nih.gov/pubmed/29713085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0010-1
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