Efficient Gene Transfer to Kidney Mesenchymal Cells Using a Synthetic Adeno-Associated Viral Vector

BACKGROUND: After injury, mesenchymal progenitors in the kidney interstitium differentiate into myofibroblasts, cells that have a critical role in kidney fibrogenesis. The ability to deliver genetic material to myofibroblast progenitors could allow new therapeutic approaches to treat kidney fibrosis...

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Bibliographische Detailangaben
Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Ikeda, Yoichiro, Sun, Zhao, Ru, Xiao, Vandenberghe, Luk H., Humphreys, Benjamin D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2018
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115653/
https://ncbi.nlm.nih.gov/pubmed/29976586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018040426
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