Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes

Hypoxia-inducible factor (HIF)-1α is essential following a myocardial infarction (MI), and diabetic patients have poorer prognosis post-MI. Could HIF-1α activation be abnormal in the diabetic heart, and could metabolism be causing this? Diabetic hearts had decreased HIF-1α protein following ischemia...

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Bibliographische Detailangaben
Veröffentlicht in:JACC Basic Transl Sci
Hauptverfasser: Dodd, Michael S., Sousa Fialho, Maria da Luz, Montes Aparicio, Claudia N., Kerr, Matthew, Timm, Kerstin N., Griffin, Julian L., Luiken, Joost J.F.P., Glatz, Jan F.C., Tyler, Damian J., Heather, Lisa C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
Schlagworte:
PRECLINICAL RESEARCH
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115650/
https://ncbi.nlm.nih.gov/pubmed/30175272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2018.04.005
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