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Programmable one-pot synthesis of heparin pentasaccharides enabling access to regiodefined sulfate derivatives

Heparin (H) and heparan sulfate (HS) belong to the glycosaminoglycan (GAG) family of oligosaccharides, and their sequences and sulfation patterns are known to regulate the functions of various proteins in biological processes. Among these, the 6-O-sulfation of HS/H contributes most significantly to...

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Pubblicato in:Chem Sci
Autori principali: Dey, Supriya, Wong, Chi-Huey
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115620/
https://ncbi.nlm.nih.gov/pubmed/30310602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01743c
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