High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis

While suppression of specific genes through aberrant promoter methylation contributes to different diseases including organ fibrosis, gene-specific reactivation technology is not yet available for therapy. TET enzymes catalyze hydroxymethylation of methylated DNA, reactivating gene expression. We he...

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Udgivet i:Nat Commun
Main Authors: Xu, Xingbo, Tan, Xiaoying, Tampe, Björn, Wilhelmi, Tim, Hulshoff, Melanie S., Saito, Shoji, Moser, Tobias, Kalluri, Raghu, Hasenfuss, Gerd, Zeisberg, Elisabeth M., Zeisberg, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115451/
https://ncbi.nlm.nih.gov/pubmed/30158531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05766-5
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