Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

Adoptive transfer experimental autoimmune encephalomyelitis (AT-EAE), a disease resembling multiple sclerosis, is induced in rats by myelin basic protein (MBP)-activated CD4(+) T lymphocytes. By patch-clamp analysis, encephalitogenic rat T cells stimulated repeatedly in vitro expressed a unique chan...

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Bibliographic Details
Main Authors: Beeton, Christine, Wulff, Heike, Barbaria, Jocelyne, Clot-Faybesse, Olivier, Pennington, Michael, Bernard, Dominique, Cahalan, Michael D., Chandy, K. George, Béraud, Evelyne
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC61146/
https://ncbi.nlm.nih.gov/pubmed/11717451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241497298
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