Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice

The development of spontaneous autoimmune diabetes in nonobese diabetic (NOD) mice provides for their use as a model of human type 1 diabetes. To test the feasibility of muscle-directed gene therapy to prevent type 1 diabetes, we developed recombinant adeno-associated virus (rAAV) vectors containing...

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Detalhes bibliográficos
Main Authors: Goudy, Kevin, Song, Sihong, Wasserfall, Clive, Zhang, Y. Clare, Kapturczak, Matthias, Muir, Andrew, Powers, Matthew, Scott-Jorgensen, Marda, Campbell-Thompson, Martha, Crawford, James M., Ellis, Tamir M., Flotte, Terence R., Atkinson, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC61141/
https://ncbi.nlm.nih.gov/pubmed/11717448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251532298
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