Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors

Recombinant adeno-associated virus (AAV) vectors have been used to transduce murine skeletal muscle as a platform for secretion of therapeutic proteins. The utility of this approach for treating alpha-1-antitrypsin (AAT) deficiency was tested in murine myocytes in vitro and in vivo. AAV vectors expr...

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Bibliografiske detaljer
Main Authors: Song, Sihong, Morgan, Michael, Ellis, Tamir, Poirier, Amy, Chesnut, Kye, Wang, Jianming, Brantly, Mark, Muzyczka, Nicholas, Byrne, Barry J., Atkinson, Mark, Flotte, Terence R.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC24382/
https://ncbi.nlm.nih.gov/pubmed/9826709
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