Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming

Epiblast cells in the early post-implantation stage mammalian embryo undergo a transition described as lineage priming before cell fate allocation, but signaling pathways acting upstream remain ill defined. Genetic studies demonstrate that Smad2/3 double-mutant mouse embryos die shortly after implan...

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Publicado en:Cell Rep
Autores principales: Senft, Anna D., Costello, Ita, King, Hamish W., Mould, Arne W., Bikoff, Elizabeth K., Robertson, Elizabeth J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113931/
https://ncbi.nlm.nih.gov/pubmed/30134160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.077
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