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Vaccination, prevention, and treatment of experimental autoimmune neuritis (EAN) by an oligomerized T cell epitope

Using a polypeptide oligomer harboring 16 repeats of the neuritogenic epitope (aa 58–73) of myelin P2 protein separated by spacers, enhancement of the immune response to the P2 protein, an important neuritogenic autoantigen in experimental autoimmune neuritis (EAN), was attempted. In contrast to a p...

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Autors principals: Stienekemeier, M., Falk, K., Rötzschke, O., Weishaupt, A., Schneider, C., Toyka, K. V., Gold, R., Strominger, J. L.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC61134/
https://ncbi.nlm.nih.gov/pubmed/11717443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241504598
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