Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress

Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis in response to endoplasmic reticulum (ER) stress; however, a recent paper challenges this conclusion. Here we validate the importance of DR5 and caspase-8 as critical signal conduits for apoptosis activatio...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Lam, Mable, Lawrence, David A., Ashkenazi, Avi, Walter, Peter
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Correspondence
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113221/
https://ncbi.nlm.nih.gov/pubmed/29991746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0155-y
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