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A novel molecular rotor facilitates detection of p53-DNA interactions using the Fluorescent Intercalator Displacement Assay

We have investigated the use of fluorescent molecular rotors as probes for detection of p53 binding to DNA. These are a class of fluorophores that undergo twisted intramolecular charge transfer (TICT). They are non-fluorescent in a freely rotating conformation and experience a fluorescence increase...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Goh, Walter L., Lee, Min Yen, Lim, Ting Xiang, Chua, Joy S., Brenner, Sydney, Ghadessy, Farid J., Teo, Yin Nah
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113202/
https://ncbi.nlm.nih.gov/pubmed/30154420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31197-9
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