Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination

Immunoglobulin class-switch recombination (CSR) gives rise to looped-out circular DNA of a cleaved S segment, which is lost eventually after cell divisions. To understand the molecular mechanism of S region cleavage during CSR, we constructed artificial CSR substrates in which inversion-type CSR tak...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chen, Xiaochuan, Kinoshita, Kazuo, Honjo, Tasuku
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC61132/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11717442/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241524898
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