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The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8(+) T Cell Tolerance Checkpoint to High-Dose Antigen
Escape from peripheral tolerance checkpoints that control cytotoxic CD8(+) T cells is important for cancer immunotherapy and autoimmunity, but pathways enforcing these checkpoints are mostly uncharted. We reveal that the HECT-type ubiquitin ligase activator, NDFIP1, enforces a cell-intrinsic CD8(+)...
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| 出版年: | Cell Rep |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6112980/ https://ncbi.nlm.nih.gov/pubmed/30021156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.060 |
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