A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice

Colitic lesions are much more severe in C3H/HeJBir (C3H) than C57BL/6J (B6) mice after 10 backcrosses of a disrupted interleukin-10 (Il10) gene. This study identified cytokine deficiency-induced colitis susceptibility (Cdcs) modifiers by using quantitative trait locus (QTL) analysis. A segregating F...

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Bibliografische gegevens
Hoofdauteurs: Farmer, Mark A., Sundberg, John P., Bristol, Ian J., Churchill, Gary A., Li, Renhua, Elson, Charles O., Leiter, Edward H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 2001
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC61125/
https://ncbi.nlm.nih.gov/pubmed/11707574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241258698
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