Deoxycholic acid activates epidermal growth factor receptor and promotes intestinal carcinogenesis by ADAM17‐dependent ligand release

High fat diet is implicated in the elevated deoxycholic acid (DCA) in the intestine and correlated with increased colon cancer risk. However, the potential mechanisms of intestinal carcinogenesis by DCA remain unclarified. Here, we investigated the carcinogenic effects and mechanisms of DCA using th...

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Pubblicato in:J Cell Mol Med
Autori principali: Dong, Wenxiao, Liu, Li, Dou, Yan, Xu, Mengque, Liu, Tianyu, Wang, Sinan, Zhang, Yujie, Deng, Baoru, Wang, Bangmao, Cao, Hailong
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6111862/
https://ncbi.nlm.nih.gov/pubmed/29956475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13709
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