ASK1 inhibitor treatment suppresses p38/JNK signalling with reduced kidney inflammation and fibrosis in rat crescentic glomerulonephritis

Activation of p38 mitogen‐activated protein kinase (MAPK) and c‐Jun amino terminal kinase (JNK) is prominent in human crescentic glomerulonephritis. p38 and JNK inhibitors suppress crescentic disease in animal models; however, the upstream mechanisms inducing activation of these kinases in crescenti...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Amos, Liv A., Ma, Frank Y., Tesch, Greg H., Liles, John T., Breckenridge, David G., Nikolic‐Paterson, David J., Han, Yingjie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6111820/
https://ncbi.nlm.nih.gov/pubmed/29998485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13705
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