Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in non-small cell lung cancer

Gasdermin D (GSDMD) is a newly discovered pyroptosis executive protein, which can be cleaved by inflammatory caspases and is essential for secretion of IL-1β, making it a critical mediator of inflammation. However, the precise role of GSDMD in carcinogenesis remains nearly unknown. Considering the v...

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Vydáno v:Oncol Rep
Hlavní autoři: Gao, Jianwei, Qiu, Xiangyu, Xi, Guangmin, Liu, Hongbing, Zhang, Fang, Lv, Tangfeng, Song, Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6111570/
https://ncbi.nlm.nih.gov/pubmed/30106450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2018.6634
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