Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to translate in a clinical setting. Consequently, t...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Front Pharmacol
Main Authors: Barbieri, Federica, Würth, Roberto, Pattarozzi, Alessandra, Verduci, Ivan, Mazzola, Chiara, Cattaneo, Maria G., Tonelli, Michele, Solari, Agnese, Bajetto, Adriana, Daga, Antonio, Vicentini, Lucia M., Mazzanti, Michele, Florio, Tullio
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2018
נושאים:
Pharmacology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110922/
https://ncbi.nlm.nih.gov/pubmed/30186163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00899
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