Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA favours a pre-metastatic microenvironment

Local acidification of stroma is proposed to favour pre-metastatic niche formation but the mechanism of initiation is unclear. We investigated whether Human Melanoma-derived exosomes (HMEX) could reprogram human adult dermal fibroblasts (HADF) and cause extracellular acidification. HMEX were isolate...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Shu, Shin La, Yang, Yunchen, Allen, Cheryl L., Maguire, Orla, Minderman, Hans, Sen, Arindam, Ciesielski, Michael J., Collins, Katherine A., Bush, Peter J., Singh, Prashant, Wang, Xue, Morgan, Martin, Qu, Jun, Bankert, Richard B., Whiteside, Theresa L., Wu, Yun, Ernstoff, Marc S.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110845/
https://ncbi.nlm.nih.gov/pubmed/30150674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31323-7
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