Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA favours a pre-metastatic microenvironment

Local acidification of stroma is proposed to favour pre-metastatic niche formation but the mechanism of initiation is unclear. We investigated whether Human Melanoma-derived exosomes (HMEX) could reprogram human adult dermal fibroblasts (HADF) and cause extracellular acidification. HMEX were isolate...

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Publicado en:Sci Rep
Main Authors: Shu, Shin La, Yang, Yunchen, Allen, Cheryl L., Maguire, Orla, Minderman, Hans, Sen, Arindam, Ciesielski, Michael J., Collins, Katherine A., Bush, Peter J., Singh, Prashant, Wang, Xue, Morgan, Martin, Qu, Jun, Bankert, Richard B., Whiteside, Theresa L., Wu, Yun, Ernstoff, Marc S.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110845/
https://ncbi.nlm.nih.gov/pubmed/30150674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31323-7
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