Targeting of BMI-1 with PTC-209 inhibits glioblastoma development

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and refractory to existing therapies. The oncogene BMI-1, a member of Polycomb Repressive Complex 1 (PRC1) plays essential roles in various human cancers and becomes an attractive therapeutic target. Here we showed that BMI-...

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Veröffentlicht in:Cell Cycle
Hauptverfasser: Kong, Yu, Ai, Chunbo, Dong, Feng, Xia, Xianyou, Zhao, Xiujuan, Yang, Chao, Kang, Chunsheng, Zhou, Yan, Zhao, Qian, Sun, Xiujing, Wu, Xudong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110607/
https://ncbi.nlm.nih.gov/pubmed/29886801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1469872
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