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Direct Force Probe for Nuclear Mechanics

We describe a recently reported method for directly applying a known, nanonewton-scale force to the nucleus in a living, intact cell. First, a suction seal is applied on the nuclear surface using a micropipette. Then, the micropipette is translated away from the nucleus. The nucleus deforms and tran...

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Bibliografiska uppgifter
I publikationen:Methods Mol Biol
Huvudupphovsmän: Tocco, Vincent J., Neelam, Srujana, Zhang, Qiao, Dickinson, Richard B., Lele, Tanmay P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6110108/
https://ncbi.nlm.nih.gov/pubmed/30141040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-8691-0_8
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