Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy

Mocholi et al. show that, following T cell activation, activation of autophagy constitutes a tolerance-avoidance mechanism that, through modulation of cell metabolism and specific signaling pathways, allows T cells to engage in effector responses and avoid anergy. In vivo inhibition of autophagy in...

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Vydáno v:Cell Rep
Hlavní autoři: Mocholi, Enric, Dowling, Samuel D., Botbol, Yair, Gruber, Ross C., Ray, Alex K., Vastert, Sebastiaan, Bridget, Shafit-Zagardo, Coffer, Paul J., Macian, Fernando
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109966/
https://ncbi.nlm.nih.gov/pubmed/30067971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.065
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