Rationale and design of the TRUSTY study: a randomised, multicentre, open-label phase II/III study of trifluridine/tipiracil plus bevacizumab versus irinotecan, fluoropyrimidine plus bevacizumab as second-line treatment in patients with metastatic colorectal cancer progressive during or following first-line oxaliplatin-based chemotherapy

BACKGROUND: Trifluridine/tipiracil is an oral agent approved for the treatment of patients with metastatic colorectal cancer (mCRC). Trifluridine is an antineoplastic thymidine analogue, and tipiracil improves its bioavailability. A phase I/II C-TASK FORCE study of trifluridine/tipiracil plus bevaci...

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Dades bibliogràfiques
Publicat a:ESMO Open
Autors principals: Yoshino, Takayuki, Oki, Eiji, Nozawa, Hiroaki, Eguchi-Nakajima, Takako, Taniguchi, Hiroya, Morita, Satoshi, Takenaka, Naruhito, Ozawa, Daisuke, Shirao, Kuniaki
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2018
Matèries:
Protocol
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109822/
https://ncbi.nlm.nih.gov/pubmed/30167332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/esmoopen-2018-000411
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