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Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease‐activated receptor 1‐ and protease‐activated receptor 4‐dependent mechanism

BACKGROUND AND PURPOSE: Thrombin is massively released upon tissue damage associated with bleeding or chronic inflammation. The effects of this thrombin on tissue regrowth and repair has been scarcely addressed and only in cancer cell lines. Hence, the purpose of the present study was to determine t...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Sébert, Morgane, Denadai‐Souza, Alexandre, Quaranta, Muriel, Racaud‐Sultan, Claire, Chabot, Sophie, Lluel, Philippe, Monjotin, Nicolas, Alric, Laurent, Portier, Guillaume, Kirzin, Sylvain, Bonnet, Delphine, Ferrand, Audrey, Vergnolle, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109216/
https://ncbi.nlm.nih.gov/pubmed/29959891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14430
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