Thrombin-Induced Podocyte Injury Is Protease-Activated Receptor Dependent

Nephrotic syndrome is characterized by massive proteinuria and injury of specialized glomerular epithelial cells called podocytes. Studies have shown that, whereas low-concentration thrombin may be cytoprotective, higher thrombin concentrations may contribute to podocyte injury. We and others have d...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Sharma, Ruchika, Waller, Amanda P., Agrawal, Shipra, Wolfgang, Katelyn J., Luu, Hiep, Shahzad, Khurrum, Isermann, Berend, Smoyer, William E., Nieman, Marvin T., Kerlin, Bryce A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2017
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576925/
https://ncbi.nlm.nih.gov/pubmed/28424276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016070789
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