Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing

Long mammalian introns make it challenging for the RNA processing machinery to identify exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection by recruiting dozens of RNA-binding proteins (RBPs) to introns. This includes MATR3, which promotes binding of PTBP1 to m...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Attig, Jan, Agostini, Federico, Gooding, Clare, Chakrabarti, Anob M., Singh, Aarti, Haberman, Nejc, Zagalak, Julian A., Emmett, Warren, Smith, Christopher W.J., Luscombe, Nicholas M., Ule, Jernej
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6108849/
https://ncbi.nlm.nih.gov/pubmed/30078707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.07.001
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