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Taxol biosynthesis: Taxane 13α-hydroxylase is a cytochrome P450-dependent monooxygenase

A central feature in the biosynthesis of Taxol is oxygenation at multiple positions of the taxane core structure, reactions that are considered to be mediated by cytochrome P450-dependent monooxygenases. A PCR-based differential display-cloning approach, using Taxus (yew) cells induced for Taxol pro...

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Autori principali: Jennewein, Stefan, Rithner, Christopher D., Williams, Robert M., Croteau, Rodney B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC61086/
https://ncbi.nlm.nih.gov/pubmed/11707604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251539398
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