Alzheimer's β-secretase, β-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

The deposition of amyloid β-peptide (Aβ) in the brain is closely associated with the development of Alzheimer's disease. Aβ is generated from the amyloid precursor protein (APP) by sequential action of β-secretase (BACE1) and γ-secretase. Although BACE1 is distributed among various other tissues, it...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Kitazume, Shinobu, Tachida, Yuriko, Oka, Ritsuko, Shirotani, Keiro, Saido, Takaomi C., Hashimoto, Yasuhiro
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2001
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC61079/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11698669/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.241509198
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