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Alzheimer's β-secretase, β-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

The deposition of amyloid β-peptide (Aβ) in the brain is closely associated with the development of Alzheimer's disease. Aβ is generated from the amyloid precursor protein (APP) by sequential action of β-secretase (BACE1) and γ-secretase. Although BACE1 is distributed among various other tissue...

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Main Authors: Kitazume, Shinobu, Tachida, Yuriko, Oka, Ritsuko, Shirotani, Keiro, Saido, Takaomi C., Hashimoto, Yasuhiro
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2001
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC61079/
https://ncbi.nlm.nih.gov/pubmed/11698669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.241509198
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