Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification

Streptococcus pneumoniae evades C3-mediated opsonization and effector functions by expressing an immuno-protective polysaccharide capsule and Factor H (FH)-binding proteins. Here we use super-resolution microscopy, mutants and functional analysis to show how these two defense mechanisms are function...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pathak, Anuj, Bergstrand, Jan, Sender, Vicky, Spelmink, Laura, Aschtgen, Marie-Stephanie, Muschiol, Sandra, Widengren, Jerker, Henriques-Normark, Birgitta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107515/
https://ncbi.nlm.nih.gov/pubmed/30139996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05494-w
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