Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice

During Coxsackievirus B3 (CVB3) infection hepatitis is a potentially life threatening complication, particularly in newborns. Studies with type I interferon (IFN-I) receptor (IFNAR)-deficient mice revealed a key role of the IFN-I axis in the protection against CVB3 infection, whereas the source of I...

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Publicado en:PLoS Pathog
Autores principales: Koestner, Wolfgang, Spanier, Julia, Klause, Tanja, Tegtmeyer, Pia-K., Becker, Jennifer, Herder, Vanessa, Borst, Katharina, Todt, Daniel, Lienenklaus, Stefan, Gerhauser, Ingo, Detje, Claudia N., Geffers, Robert, Langereis, Martijn A., Vondran, Florian W. R., Yuan, Qinggong, van Kuppeveld, Frank J. M., Ott, Michael, Staeheli, Peter, Steinmann, Eike, Baumgärtner, Wolfgang, Wacker, Frank, Kalinke, Ulrich
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107283/
https://ncbi.nlm.nih.gov/pubmed/30075026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007235
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