PD-L1, TIM-3, and CTLA-4 Blockade Fails To Promote Resistance to Secondary Infection with Virulent Strains of Toxoplasma gondii

T cell exhaustion is a state of hyporesponsiveness that develops during many chronic infections and cancer. Neutralization of inhibitory receptors, or “checkpoint blockade,” can reverse T cell exhaustion and lead to beneficial prognoses in experimental and clinical settings. Whether checkpoint block...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Splitt, Samantha D., Souza, Scott P., Valentine, Kristen M., Castellanos, Brayan E., Curd, Andrew B., Hoyer, Katrina K., Jensen, Kirk D. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105904/
https://ncbi.nlm.nih.gov/pubmed/29967089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00459-18
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