Caspase-1 and Caspase-11 Mediate Pyroptosis, Inflammation, and Control of Brucella Joint Infection

Brucellosis, caused by the intracellular bacterial pathogen Brucella, is a zoonotic disease for which arthritis is the most common focal complication in humans. Here we investigated the role of inflammasomes and their effectors, including interleukin-1 (IL-1), IL-18, and pyroptosis, on inflammation...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Lacey, Carolyn A., Mitchell, William J., Dadelahi, Alexis S., Skyberg, Jerod A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Host Response and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105886/
https://ncbi.nlm.nih.gov/pubmed/29941463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00361-18
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