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Synergetic improvements of sensitivity and specificity of nanowire field effect transistor gene chip by designing neutralized DNA as probe

Neutral DNA analogs as probes for the detection of target oligomers on the biosensors based on the field-effect transistor (FET) configuration feature advantages in the enhancement of sensitivity and signal-to-noise ratio. Herein, we used phosphate-methylated nucleotides to synthesize two partially...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hu, Wen-Pin, Tsai, Chih-Chin, Yang, Yuh-Shyong, Chan, Hardy Wai-Hong, Chen, Wen-Yih
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105729/
https://ncbi.nlm.nih.gov/pubmed/30135473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30996-4
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