Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration

Critical functions of intra-axonally synthesized proteins are thought to depend on regulated recruitment of mRNA from storage depots in axons. Here we show that axotomy of mammalian neurons induces translation of stored axonal mRNAs via regulation of the stress granule protein G3BP1, to support rege...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Sahoo, Pabitra K., Lee, Seung Joon, Jaiswal, Poonam B., Alber, Stefanie, Kar, Amar N., Miller-Randolph, Sharmina, Taylor, Elizabeth E., Smith, Terika, Singh, Bhagat, Ho, Tammy Szu-Yu, Urisman, Anatoly, Chand, Shreya, Pena, Edsel A., Burlingame, Alma L., Woolf, Clifford J., Fainzilber, Mike, English, Arthur W., Twiss, Jeffery L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105716/
https://ncbi.nlm.nih.gov/pubmed/30135423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05647-x
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