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KLF6 and STAT3 co-occupy regulatory DNA and functionally synergize to promote axon growth in CNS neurons

The failure of axon regeneration in the CNS limits recovery from damage and disease. Members of the KLF family of transcription factors can exert both positive and negative effects on axon regeneration, but the underlying mechanisms are unclear. Here we show that forced expression of KLF6 promotes a...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Wang, Zimei, Mehra, Vatsal, Simpson, Matthew T., Maunze, Brian, Chakraborty, Advaita, Holan, Lyndsey, Eastwood, Erik, Blackmore, Murray G., Venkatesh, Ishwariya
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105645/
https://ncbi.nlm.nih.gov/pubmed/30135567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31101-5
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