Programmed death-1 receptor signaling downregulates asparaginyl endopeptidase to maintain Foxp3 stability in induced Regulatory T cells

CD4(+) T cell differentiation into multiple T helper cell (Th) lineages is critical for optimal adaptive immune responses. This report identifies an intrinsic mechanism by which programmed death-1 receptor (PD-1) signaling imparted regulatory phenotype to Foxp3(+) Th1 cells (denoted as Tbet(+)iTreg(...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Stathopoulou, Chaido, Gangaplara, Arunakumar, Mallett, Grace, Flomerfelt, Francis A., Liniany, Lukasz P., Knight, David, Samsel, Leigh A., Berlinguer-Palmini, Rolando, Yim, Joshua J., Felizardo, Tania C., Eckhaus, Michael A., Edgington-Mitchell, Laura, Martinez-Fabregas, Jonathan, Zhu, Jinfang, Fowler, Daniel H., van Kasteren, Sanders I., Laurence, Arian, Bogyo, Matthew, Watts, Colin, Shevach, Ethan M., Amarnath, Shoba
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105434/
https://ncbi.nlm.nih.gov/pubmed/30054205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.05.006
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados