A randomised placebo-controlled double-blind trial to assess the safety of intramuscular administration of allogeneic mesenchymal stromal cells for digital ulcers in systemic sclerosis: the MANUS Trial protocol

INTRODUCTION: Systemic sclerosis (SSc) is an autoimmune disease characterised by inflammation, fibrosis and vasculopathy. Digital ulcers (DUs) are a frequent manifestation of vasculopathy in patients with SSc. Despite recent advances in pharmacological treatments, DU still have major health and econ...

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Detalhes bibliográficos
Publicado no:BMJ Open
Main Authors: van Rhijn-Brouwer, Femke C C, Gremmels, Hendrik, Fledderus, Joost O, Schuurman, Arnold H, Bonte-Mineur, Femke, Vonk, Madelon C, Voskuyl, Alexandre E, de Vries-Bouwstra, Jeska K, Coert, J Henk, Radstake, Timothy R D J, van Laar, Jacob M, Verhaar, Marianne C
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Rheumatology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104757/
https://ncbi.nlm.nih.gov/pubmed/30127049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2017-020479
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