Resetting the T Cell Compartment in Autoimmune Diseases With Autologous Hematopoietic Stem Cell Transplantation: An Update

Autologous hematopoietic stem cell transplantation (aHSCT) for autoimmune diseases has been applied for two decades as a treatment for refractory patients with progressive disease. The rationale behind aHSCT is that high-dose immunosuppression eliminates autoreactive T and B cells, thereby resetting...

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Detalhes bibliográficos
Main Authors: Lisanne Lutter, Julia Spierings, Femke C. C. van Rhijn-Brouwer, Jacob M. van Laar, Femke van Wijk
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-04-01
Colecção:Frontiers in Immunology
Assuntos:
autologous hematopoietic stem cell transplantation
autoimmune disease
T cell reconstitution
T cell receptor repertoire
regulatory T cell
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00767/full
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