Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ

OBJECTIVES: One mechanism by which cartilage responds to mechanical load is by releasing heparin-bound growth factors from the pericellular matrix (PCM). By proteomic analysis of the PCM, we identified connective tissue growth factor (CTGF) and here investigate its function and mechanism of action....

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Tang, Xiaodi, Muhammad, Hayat, McLean, Celia, Miotla-Zarebska, Jadwiga, Fleming, Jacob, Didangelos, Athanasios, Önnerfjord, Patrik, Leask, Andrew, Saklatvala, Jeremy, Vincent, Tonia L
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104679/
https://ncbi.nlm.nih.gov/pubmed/29925506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-212964
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