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Synthesis and in vitro and in vivo evaluation of urea-based PSMA inhibitors with increased lipophilicity

BACKGROUND: Several radiolabeled prostate-specific membrane antigen (PSMA) inhibitors based on the lysine-urea-glutamate (KuE) motif as the pharmacophore proved to be suitable tools for PET/SPECT imaging of the PSMA expression in prostate cancer patients. PSMA I&T, a theranostic tracer developed...

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Foilsithe in:EJNMMI Res
Main Authors: Wirtz, Martina, Schmidt, Alexander, Schottelius, Margret, Robu, Stephanie, Günther, Thomas, Schwaiger, Markus, Wester, Hans-Jürgen
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer Berlin Heidelberg 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104465/
https://ncbi.nlm.nih.gov/pubmed/30136051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-018-0440-2
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