Host Defense Peptide LL-37-Mediated Chemoattractant Properties, but Not Anti-Inflammatory Cytokine IL-1RA Production, Is Selectively Controlled by Cdc42 Rho GTPase via G Protein-Coupled Receptors and JNK Mitogen-Activated Protein Kinase

The human host defense peptide LL-37 promotes immune activation such as induction of chemokine production and recruitment of leukocytes. Conversely, LL-37 also mediates anti-inflammatory responses such as production of anti-inflammatory cytokines, e.g., IL-1RA, and the control of pro-inflammatory cy...

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Publicado en:Front Immunol
Autores principales: Hemshekhar, Mahadevappa, Choi, Ka-Yee Grace, Mookherjee, Neeloffer
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104452/
https://ncbi.nlm.nih.gov/pubmed/30158931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01871
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