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Deletion of Ezrin in B cells of Lyn-deficient mice downregulates lupus pathology()

Genetic deletion of the Src family tyrosine kinase Lyn in mice recapitulates human systemic lupus erythematosus, characterized by hyperactive B cell antigen receptor (BCR) signaling, splenomegaly, autoantibody generation and glomerulonephritis. However, the molecular regulators of autoimmunity in Ly...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Pore, Debasis, Huang, Emily, Dejanovic, Dina, Parameswaran, Neetha, Cheung, Michael B., Gupta, Neetu
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103798/
https://ncbi.nlm.nih.gov/pubmed/30021765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800168
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