Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency

The accumulation of undegraded molecular material leads to progressive neurodegeneration in a number of lysosomal storage disorders (LSDs) that are caused by functional deficiencies of lysosomal hydrolases. To determine whether inducing macroautophagy/autophagy via small-molecule therapy would be ef...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Lotfi, Parisa, Tse, Dennis Y., Di Ronza, Alberto, Seymour, Michelle L., Martano, Giuseppe, Cooper, Jonathan D., Pereira, Fred A., Passafaro, Maria, Wu, Samuel M., Sardiello, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper - Translational
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103706/
https://ncbi.nlm.nih.gov/pubmed/29916295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1474313
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