HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC

Macroautophagy/autophagy has emerged as a resistance mechanism to anticancer drug treatments that induce metabolic stress. Certain tumors, including a subset of KRAS-mutant NSCLCs have been shown to be addicted to autophagy, and potentially vulnerable to autophagy inhibition. Currently, autophagy in...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Han, Jie, Goldstein, Leslie A., Hou, Wen, Chatterjee, Suman, Burns, Timothy F., Rabinowich, Hannah
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper - Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103412/
https://ncbi.nlm.nih.gov/pubmed/29561705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1434471
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