Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells

Targeting TRAIL receptors with either recombinant TRAIL or agonistic DR4- or DR5-specific antibodies has been considered a promising treatment for cancer, particularly due to the preferential apoptotic susceptibility of tumor cells over normal cells to TRAIL. However, the realization that many tumor...

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Bibliografische gegevens
Hoofdauteurs: Han, Jie, Hou, Wen, Goldstein, Leslie A., Lu, Caisheng, Stolz, Donna B., Yin, Xiao-Ming, Rabinowich, Hannah
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2008
Onderwerpen:
Mechanisms of Signal Transduction
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443661/
https://ncbi.nlm.nih.gov/pubmed/18375389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710169200
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